Adverse events following ChAdOx1 nCoV-19 (Covisheild) vaccine administered in two-dose regimen: A single centre experience from Sri Lanka
نویسندگان
چکیده
Introduction Phased distribution of the ChAdOx1nCoV-19 (Covisheild) vaccine was commenced in Sri Lanka January 2021. Although well tolerated with a low reactogenicity profile clinical trials, there were safety concerns shortly after initiating rollouts many countries. Objectives This prospective observational study aimed to adverse events following immunization (AEFI) amongst recipients between 30th 5th February at University Hospital, KDU. The associations AEFI also evaluated. Methods A cohort 688 followed up till completion vaccination. Data collected using an interviewer-administered questionnaire and through telephone interviews. classified according WHO criteria. Results total 516(74.9%) participants experienced first dose, which 377(73.0%) reported both systemic local symptoms. By contrast, incidence significantly lower second dose (n=134,21.1%, p<0.001). Fever being commonest event (n=389,75.2%), injection site pain frequent (n=85,63.43%) dose. Of four serious (0.6%) two had seizures. predominantly occurred within 24 hours each (77.1% 67.9%, respectively) lasted less than 72 majority (79.1% 81.3%, respectively). higher females (P=0.007). Conclusions our population expected trials. absence life-threatening indicates good vaccine.
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ژورنال
عنوان ژورنال: Journal of the Ceylon College of Physicians
سال: 2022
ISSN: ['2448-9514']
DOI: https://doi.org/10.4038/jccp.v53i1.7946